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Which human leukocyte antigen (HLA) allele is most strong... | QuestionStock

Representative image for question: Which human leukocyte antigen (HLA) allele is most strongly associated with ankylosing spondylitis?

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Medicine

Which human leukocyte antigen (HLA) allele is most strongly associated with ankylosing spondylitis?

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Which human leukocyte antigen (HLA) allele is most strongly associated with ankylosing spondylitis?

Options:

HLA‑B27
HLA‑DR3
HLA‑DR4
HLA‑B8

Correct answer: HLA‑B27

Explanation: HLA‑B27 is strongly associated with ankylosing spondylitis and is present in about 90% of affected patients; this class I MHC allele markedly increases susceptibility to axial spondyloarthropathy.

Created 2026-03-10T17:31:55.853Z. Updated 2026-03-10T17:31:55.853Z.