
Which class of diuretics primarily inhibits the Na+/Cl− cotransporter in the distal convoluted tubule?
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Get StartedWhich class of diuretics primarily inhibits the Na+/Cl− cotransporter in the distal convoluted tubule?
Options:
- Thiazide diuretics
- Loop diuretics
- Potassium‑sparing diuretics
- Carbonic anhydrase inhibitors
Correct answer: Thiazide diuretics
Explanation: Thiazide diuretics (eg, hydrochlorothiazide) block the thiazide‑sensitive Na+/Cl− cotransporter (NCC) in the distal convoluted tubule and increase calcium reabsorption; they commonly cause hypokalemia.
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